One- and two-day dosing intervals between mifepristone and misoprostol in second trimester medical termination of pregnancy--a randomized trial
نویسندگان
چکیده
منابع مشابه
A randomized trial to compare two dosing intervals of misoprostol following mifepristone administration in second trimester medical abortion.
BACKGROUND The conventional timing of misoprostol administration after mifepristone for second trimester medical abortion is 36-48 h, but simultaneous administration, which may make the regimen more convenient, has not been studied. The objective of this randomized comparison study is to compare two intervals of administration of misoprostol after pretreatment with mifepristone for second trime...
متن کاملDifferent Time Schedules of Mifepristone and Misoprostol in Second Trimester Medical Abortion: A Comparative Study
Background & aim: Recently, the use of mifepristone followed by misoprostol after 36-48 h has been demonstrated to be an effective and safe method for the second trimester medical abortion. However, this regimen entails long total abortion time, and consequently increases the financial burden and anxiety in the patients. We hypothesize that one day interval would be also effective and can be us...
متن کاملvaginal versus oral misoprostol for second-trimester pregnancy termination: a randomized trial
introduction: the purpose of this study was to compare the efficacy and side effects of two different misoprostol regimens for second-trimester pregnancy termination. methods: 60 consenting women who were at 14 to 28 weeks of gestation with indications for pregnancy termination were randomly assigned to two equal groups to receive either vaginal or oral misoprostol. the dosing regimen was 400µg...
متن کاملTwo mifepristone doses and two intervals of misoprostol administration for termination of early pregnancy: a randomised factorial controlled equivalence trial.
OBJECTIVE To compare the efficacy of 100 mg and 200 mg of mifepristone and 24- and 48-hour intervals to administration of 800 microg vaginal misoprostol for termination of early pregnancy. DESIGN Placebo-controlled, randomized, equivalence trial, stratified by centre. SETTING 13 departments of obstetrics and gynecology in nine countries. POPULATION 2,181 women with 63 days or less gestati...
متن کاملEmbryonic abnormalities at medical termination of pregnancy with mifepristone and misoprostol during first trimester: observational study.
The availability of new medical techniques for induced abortion in the first trimester enables observation of the incidence and nature of embryonic and fetal abnormalities in early pregnancy. 506 women, presenting to the Liverpool (England) Women's Hospital in 1994-96 for induced abortion before 9 weeks of gestation, were given oral mifepristone followed by oral misoprostol. Fetal tissue was ...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2011
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/der218